What would be the major drawback to taking too many antacids? just as heat can denature enzymes, so can a change in the ph. enzymes that normally work in an acidic environment in the body can become denatured if the ph becomes too alkaline. and enzymes that normally work in alkaline environments in the body can become denatured if the ph becomes too acidic. taking an antacid to reduce the acidity (and increase the ph) of the stomach and to relieve heartburn can make a person more comfortable. what would be the major drawback to taking too many antacids? it is doubtful that taking too many antacids could have any negative effect on the body. taking too many antacids could make stomach enzymes more powerful. taking too many antacids can change the way food tastes. taking too many antacids could denature the enzymes that break down food in the stomach?