when you mention the coefient of the squared term, I assume you mean the value of a in y=a(x-h)²+k and not the value of a in y=ax²+bx+c (actually they are the same)
so
using vertex form
y=a(x-h)²+k
vertex is (h,k)
so, given vertex of (4,-3)
y=a(x-4)²-3
also, a point is when x=5, y=-6 so (5,-6) is a point
sub to find a
-6=a(5-4)²-3
-6=a(1)²-3
-6=a-3
-3=a
so the answer is C