The instruction that is most important to include when teaching how to self administer a mixture of two insulin types would be to draw up the isophane suspension insulin first and then regular insulin into the same insulin syringe. It should be noted that when mixing two types of insulin, the order of how they are being mixed should be constant or the same in every administration in order to have a consistent mixture everytime. It is very important to take note of every step that is said by the professional in administering insulin and to be very careful during the administration in order to avoid any complications.