The Three leading causes of death, today in the United States, first is the Cardiovascular diseases or Heart disease, second in line is Cancer, while third in line is Chronic Obstructive Pulmonary diseases or Chronic Lower Respiratory disease. There are around 610,000 deaths related to heart diseases every year in the U.S. There are around 564,000 deaths related to cancer every year in the U.S. While there are 147,000 deaths related to Chronic Lower Respiratory disease.