Answer: The correct answer is Carbohydrate.
Amylase is a digestive enzyme, which helps in the digestion of carbohydrates. In humans, it is secreted in the mouth ( salivary amylase) by salivary glands, and pancreas ( pancreatic amylase, which works in the small intestine).
The complex carbohydrate like starch is targeted by this enzyme, which converts it into simple sugar like maltose. This enzyme works best at pH 7.
Thus, the macromolecules carbohydrates are targeted by the enzyme amylase.