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A major reason for the issuance of the monroe doctorine 1823 was to

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A major reason for the issuance of the monroe doctorine 1823 was to: prevent further European colonization in the Caribbean region.
According to the Monroe doctrine, European expansion of power toward south America will became a threat for the United States and should be viewed as "the manifestation of an unfriendly disposition toward the United States."
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