The solution would be like this for this specific problem:
Given: n (objects) = 555
r (sample) = 222
C (n, r) = C (555, 222)

= 5.711721253E+160
555 nCr 222 = 57117212533893475550611833988747426677146826761372763318735580307112179904951840423061305996599436547564283744124639707802221628272320974048311192258663900904000
So there are 57117212533893475550611833988747426677146826761372763318735580307112179904951840423061305996599436547564283744124639707802221628272320974048311192258663900904000 different groups of friends that you could take with you.