Question

According to the CDC, smoking can lead to Buerger's disease, which affects blood vessels in the arms and legs. Blood vessels swell, which can prevent blood flow, causing clots to form. This can lead to pain and tissue damage. Extreme cases can induce gangrene, which can require amputation. What statement best replaces the sentence, "Extreme cases can induce gangrene, which can necessitate amputation?" Extreme cases can be caused by gangrene, which involves the removal of a limb. Extreme cases can lead to gangrene, which can require removal of a limb. Extreme cases can be caused by gangrene, which requires increased care. Extreme cases can lead to gangrene, which involves involuntary care.

Answer 1

Extreme cases can lead to gangrene, which can require removal of a limb.

Answer 2

The right option is; Extreme cases can lead to gangrene, which can require removal of a limb.

“Extreme cases can lead to gangrene, which can require removal of a limb” is the statement that best replaces the sentence. Buerger's disease is a rare illness of the arteries and veins in the arms and legs that usually affect smokers. This disease can damage the skin tissues and may result in gangrene (death of body tissues) which can make all or part of a limb to be amputated (removed).