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What is the main difference between prokaryotic cells and eukaryotic cells?

User Eddie Kuo
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Prokaryotic cells don't have their DNA material (chromosomes) enclosed in a nucleus, whereas eukaryotic cells all have a nucleus. 
User Guinther Kovalski
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Answer:

The main difference between a prokaryotic cell and a eukaryotic cell is that eukaryotic cells have nuclei, while prokaryotic cells do not. Additionally, eukaryotic cells contain membrane-bound organelles, while prokaryotic cells do not.

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