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Which American Indian nation resisted removal in a way that most hurt the U.S. efforts in the Southeast?

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In the 1830 the united states was a prosperous and rapidly growing nation with an unquenchable desire for new lands to settle. In that year president andrew jackson signed into law the indian removal act, which provided for the general resettlement of eastern native americans to land west of the mississippi river.
User Rui Marinho
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The correct answer is the Cherokee Indian.
User Qifan Guo
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