Final answer:
The pH at the midpoint in the titration of a weak acid or base is equal to the pKa (or pKb) of the substance being titrated, which also represents the formation of a buffer in the solution.
Step-by-step explanation:
The pH at the midpoint in the titration of a weak acid or a weak base occurs when exactly half of the substance has been neutralized. This is the point on the titration curve where the concentration of the weak acid [HA] is equal to the concentration of its conjugate base [A-], which results in the formation of a buffer. At the midpoint, pKa equals the pH, meaning the pH value will be identical to the pKa value of the acid or base being titrated. Titration curves visually represent this phenomenon, clearly showing a flat region at the midpoint due to the buffer effect. Consequently, titrations can be used not only to determine the concentration of a weak acid or base but also its pKa (or pKb).