The Feminine Mystique by Betty Friedan talks about how empty were the lifes of all most women during the '50s and how it was considered as fulfillment for them according to society to be a wife and a mother.
After taking this in consideration de correct connotation of desperation is negative, because the woman is expressing hopelessness.
It has a negative impact because women were feeling unsatisfied with their lifes at the moment, this absolutely eliminates the last to options as a possible answer and the first option doesn't quite express what the woman was feeling or conveying.