Answer:
The answer is letter C) It even appears in the title of the famous play Arsenic and Old Lace.
Step-by-step explanation:
Option C) It even appears in the title of the famous play Arsenic and Old Lace was placed in a strange position, not following the logical order of the paragraph.
The paragraph begins by telling readers that arsenic is the favorite poison of mystery writers. It would be only logic to place the sentence in letter C right after such an introduction, since it would complete that train of thought. Then, the paragraph moves on to telling readers that the poison has been used to kill people in real life. It is illogical to mention the play Arsenic and Old Lace after the topic has been changed from fiction to real life.