The Black Death (1347-1350) was a pandemic that devastated the populations of Europe and Asia. The plague was an unprecedented human tragedy in Italy. It not only shook Italian society, but transformed it. The Black Death marked an end of an era in Italy, its impact was profound and it resulted in wide-ranging social, economic, cultural and religious changes.[1] These changes, directly and indirectly, led to the emergence of the Renaissance, one of the greatest epochs for art, architecture, and literature in human history.