Answer: The option that best represents the correct cause-and-effect relationship is D. one cause and many events.
Explanation: The passage provided includes sentences that represent a cause-and-effect relationship. A cause-and-effect relationship consists in one or more events that are the result of another event. In this case, "Isaac forgot to fill up his car with gas" is the only cause, while "he had to reschedule his appointment", "his wife left work early to take him to a gas station", and "the car was stalled on a busy road" are the effects of that cause. Therefore, the correct answer is D. since this passage includes one cause and many effects.