How do chromosomes of eukaryotes compare with chromosomes of prokaryotes? A. Eukaryotes have chromosomes floating free in the cytoplasm, whereas prokaryotes have a circular DNA inside of a nucleus. B Eukaryotes have a single chromosome, whereas prokaryotes have a number of chromosomes. C Eukaryotes have chromosomes made of DNA and proteins in a condensed form, whereas prokaryotes have a twisted circular loop of DNA. DÂ Eukaryotes have chromosomes in the form of a ring, whereas prokaryotes have condensed chromatin in their chromosomes.