Answer :
The following sentence best helps readers determine the central idea of the paragraph :
“Perhaps the most difficult thing to come to terms with is the scale of death.”
The whole paragraph talks about the Mortality Rate of Elizabethan flu. This is shown in the following points :
1. In the ten month period from August 1558 to May 1559 the annual death rate almost trebles. It increases from 2.5 percent to 7.2 percent.
2. More than 5 percent of the population dies from it. This is more than 150,000 individuals.
3. The Elizabethan flu of 1557-59 has a high mortality rate of 4.7 percent as compared to the mortality rate of 0.53 percent of the 1918-19 influenza pandemic.