I'm guessing you mean 2/5 x (-2 5/12), not 2/5x - 2 5/12.
First change the mixed number into improper form: 2 5/12 = 149/12
Now multiply together: 2/5 x 149/12 = 298/60
Lastly, convert into mixed fraction (unless your question states otherwise): 298/60 = 4 8/60
Your final answer will be: 4 8/60 or 4 4/30 simplified