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Why is the case of Marbury v. Madison significant?

It was the last time that the U.S. Supreme Court ruled a law unconstitutional.
It was the case that ended segregation in the United States.
It was the case that started segregation in the United States.
It was the first time that the U.S. Supreme Court ruled a law unconstitutional.

User Croolsby
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Well it was significant because of judicial review
User Lznt
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It was the first time that the U.S. Supreme Court ruled a law unconstitutional.

User Frederique
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