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Ted Kennedy fought a brain tumor for over a year however he died on August 25, 2009. Which is the best way to correctly punctuate this sentence?

User Greenhat
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Ted Kennedy fought a brain tumor for over a year, However he died on August 25, 2009.
User IamOgunyinka
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Ted Kennedy fought a brain tumor for over a year; however, he died on August 25, 2009.
User K D
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