The main reason it was son important was because: it offered a way to transport goods from the center of the continent.
During the nation's growing era navigation through the Mississippi River became very important since it was cheaper to ship cargo by river than by land over the Appalachian Mountains. This was during most part of the 1800's. It was up until 1870's that railroads gained more relevance than Mississippi River as the most important commerical transportation mode in Central U.S.