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Compounds that inhibit receptors by preventing the natural messenger from binding are known as

User Hans Glick
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Compounds that inhibit receptors by preventing the natural messenger from binding are known as antagonist.

Antagonists are molecules that will block the binding of the natural messenger at a receptor molecule. As a result, the signal which is usually produced by a receptor-messenger coupling will be inhibited. An antagonist can be a drug that blocks a biological response by binding to and blocking a receptor.
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