Answer:
The total number of 2-letter combinations can be created from the distinct letters in the word mathematician=28.
Explanation:
We are given that a word "mathematician".
We have to find the number of 2-letter combinations can be created from the distinct letters in the given word.
We have total letters in the word mathematician =13
Total number of distinct letter in the word mathematician =m,a,t,h,e,i,c,n=8
We have find the total number of combination of 2 letters out of 8 distinct letter by using combination formula
Combination formula:

We have n=8 and r=2
Therefore , total number of combination from 2 -letters out of 8 letters=

The total number of combinations from 2-letters out of 8 distinct letters =

The total number of combinations from 2 -letters out of 8 distinct letters=
.
Hence, the number of 2-letters combinations can be created from distinct letters in the word mathematician =28.