CIPA have huge impact on other human body systems particularly in the muscular, skeletal and digestive system. In the muscular system, the body cannot recognize or feel that a ligament is tore or if there is a strained muscle. Same with the skeletal system where the body would not be able to notify the brain that there was a broken bone or a fracture occur. Moreover, the effect of CIPA in the digestive system is that it cannot create the feeling of cramps for the discomfort of gas.