Question

What territory was the site of numerous Spanish missions but was severely depopulated in the 17th century by infectious disease and warfare with other Indian tribe?

Answer 1

Its just Mocama though.

Answer 2

The Mocama province

The Mocama Province was faced by a number of challenges that led to a sharp decline in its population. It was first plagued by a an infectious disease.In addition, there were series of war between the Spanish colonialists and the English crown forces in the North. Remnant refugees from the province were resettled at st. Augustine.