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Which was a major effect of the fall of Constantinople to the Ottoman Turks in 1453?

Europe lost access to overland trade routes to Asia.

Europe mobilized to retake Constantinople soon after.

The Byzantine Empire rebuilt itself and regained Constantinople.

Centuries of widespread persecution of Jews and Christians occurred.

User Todd Davis
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Europe lost access to overland trade routes to Asia

User Olabode
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The answer is Centuries of widespread persecution of Jews and Christians occurred.

User Babcool
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