Question

​the personality characteristic of ____, associated with rebelliousness, novelty-seeking, risk-taking and impulsivity, increases risk of substance use.

Answer 1

I believe the answer is: Behavioral undercontrol

Behavioral undercontrol refers to the tendency among individuals to constantly seeking excitement and acted based on impulses.
Having this tendency would increase the likelihood of someone doing rebellious behavior, drinking alcohol, using drugs, aggression toward other people, etc.