What is the difference between a chromatid and a chromosome? see section 12.1 ( page 255) . what is the difference between a chromatid and a chromosome? see section 12.1 ( page 255) . chromatids consist of dna, whereas chromosomes consist of proteins. a chromatid always consists of two linear dna molecules, whereas a chromosome always consists of just one linear dna molecule. chromosomes are always replicated, whereas chromatids are not. a chromatid is one half of a replicated chromosome, whereas a chromosome consists of dna wrapped around proteins in a highly organized manner?