Antifungal drugs such as miconazole and amphotericin B function by disrupting the plasma membrane. Miconazole are drugs used to treat vaginal yeast infections. They reduce vaginal burning, itching, and discharge that may occur with this condition. Amphotericib B on the other hand , is an antifungal used for serious fungal infections and leishmaniasis. It is used to treat fungal infections such as aspergillosis, candidiasis, and cryptococcosis among others.