The Endocrine disorder is frequently the cause of secondary osteoporosis, they considered in a different diagnosis and osteopenia management. Most population affected of osteoporosis are women, 68 percent of the 44 million people. Usually over the age of 50 had an osteoporosis related fracture in their lifetime. Endocrine system can help to take care the patient because it is a group of glands of organism that secretes those hormones into the circulatory system then towards the distant target organs.