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What problem did scientists have with getting podophyllotoxin from the Himalayan mayapple for cancer treatment?

User Alpakyol
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the Himalayan mayapple is not an easy plant to get hold of. Yet we humans keep trying, because the poisonous plant also naturally produces podophyllotoxin, a preliminary compound in etoposide—classed as an essential medicine by the World Health Organization (WHO)
User Ashish Shah
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