Answer:
They differ in sex chromosomes.
Step-by-step explanation:
There are two types of chromosomes; autosomes(22 pairs) and sex chromosomes(1 pair).
While all the autosomes are same in the case of both male and female humans, sex chromosomes differ.
Human male has one X and one Y chromosome, while human female has two X chromosomes. Y is roughly shorter by half than the X chromosome.