Interphase chromosomes contain both darkly staining heterochromatin and more lightly staining euchromatin.
Heterochromatin is a form of chromatin that is tightly packed DNA. This can be found in the nucleus of a eukaryotic cell. It differs from euchromatin because euchromatin is lightly packed or it is highly decondensed chromatin. Euchromatin is not readily stainable and is found in cells that are active in the transportation of their genes.
Genes that are being transcribed are thought to be packaged in a less condensed type of euchromatin. Nucleosome core particles are separated from each other by stretches of linker DNA, a double stranded DNA that is found in between two nucleosome cores.
A string of nucleosomes coils up with the help of histone H1. H1 links nucleosomes to form higher order structures or to form the more compact structure of the 30 nm fiber. The zigzag model describes the structure of the 30-nm fiber. The 30 nm chromatin fiber is further compacted by the formation of loops that emanate from a central axis.