Step 1: Let us assign variable for the unknown that we need to find.
' x ' be the actual distance between Los Angeles and San Francisco
Step 2: Set up an equation based on the given statement "The scale on a map is 1 cm:35 mi. The distance on the map between Los Angeles, CA, and San Francisco, CA, is 10.8 cm."

Conclusion:
The actual distance between Los Angeles and San Francisco is 378 miles.