The significance of Lotto's painting, Lady with a Drawing of Lucretia, is important because unlike the other paintings of Lucretia at the time that centered on eroticism, this painting signified the regal dignity of a woman's beauty and her virtue. It also portrays Lucretia, the subject of the photo, reminding her viewers of the importance of marital fidelity. Though the drawing in her hand and the Latin writing on the table she is gesturing at is reminding women to be submissive to their husbands, her posture and expression of independence are a jarring contrast to that and suggest that she is a woman of strong character and independence.