Answer:
When Christopher Columbus discovered America, he and his sailors were surprised to see the Native Indian practising old method and living in civilization. In the beginning, Spaniards were friendly to the native as they both exchanged goods.
Native American after coming to contact with the Spaniards became sick and died because of the diseases like smallpox, measles, chickenpox, plague, typhus, and malaria, which Native Indians did not have immune to fight.
With the arrival of conquistadors in New World, the relation between the Native Indian changed into hostile.