Question

Take a look at the following table:

LD50 (milligrams) ED50 (milligrams)

Drug A 200 60

Drug B 120 10

Drug C 240 2

Which drug has the greatest margin of safety?

A. Drug B

Answer 1

Answer: Drug C has the greatest margin of safety

Step-by-step explanation:

Lethal dose,
`LD_(50)`: An amount of drug which is sufficient to kill 50% of the population of animals in a fixed period of a time.

Effective dose,
`ED_(50)`: An amount of a drug which produces therapeutic response on the 50% of the population of animals ingested with that drug.

Margin of safety : It is the therapeutic index value which tells us about how safely we can use the drug for therapeutic purpose with minimal adverse effect at the same time .

Higher the value T.I safer will be the drug to use.

Lower the value T.I less safer will be the drug to use.

`T.I.=(LD_(50))/(ED_(50))`

`T.I._A=3.33,T.I._B=12,T.I._C=120`

Drug C has the greatest margin of safety