Final answer:
Lactic acid build up in muscles indicates exhaustion of energy reserves and increased levels of lactic acid due to anaerobic respiration, which is part of the body's adaptation to intense physical activity.
Step-by-step explanation:
Lactic acid build up in muscles is a sign that there is an exhaustion of energy reserves and buildup of lactic acid levels. When muscles are exerted intensely and oxygen levels are low, cells perform lactic acid fermentation, an anaerobic process that allows the production of ATP, which is crucial for continuing muscular activity. This process is catalyzed by the enzyme lactate dehydrogenase (LDH) and converts pyruvic acid into lactic acid, helping to regenerate NAD+ for glycolysis to continue. Initially, an accumulation of lactic acid was thought to cause muscle discomfort, but current studies suggest that high levels contribute to fatigue rather than cause it directly. After the intense activity, the lactic acid is transported out of the muscles, sent to the liver, and then converted back into pyruvic acid, where it can be used in further metabolic processes for energy.