Answer:
41,947,059 samples contain at least four defective parts.
Explanation:
The order of the parts are not important, and they are chosen without replacement. So the combinations formula is used to solve this question.
Combinations formula:
is the number of different combinations of x objects from a set of n elements, given by the following formula.

4 defective parts:
There are 10 parts chosen, of 50 in total.
We want 4 defective, from a set of 5.
And 10-4 = 6 non-defective, from a set of 50-5 = 45. So

5 defective parts:
5 defective, from a set of 5.
5 non-defective, from a set of 45. So

How many samples contain at least four defective parts.
40725300 + 1221759 = 41,947,059
41,947,059 contain at least four defective parts.