The correct answers are A) It involved the mistreatment of millions of slaves captured over the course of 300 years and C) Two million slaves may have died of disease and mistreatment as they crossed the Atlantic.
The statements that accurately describe the toll of the Middle Passage are the following: "It involved the mistreatment of millions of slaves captured over the course of 300 years and two million slaves may have died of disease and mistreatment as they crossed the Atlantic."
The Middle Passage was the different ocean routes that ships used to transport slaves from Africa to the Americas from 1500 to 1850. Historians think that almost 11 million slaves were transported through these routes. Thousands of slaves died during this time due to the unhealthy and precarious conditions in which they were transported.