Question

A client's laboratory findings showed increase in serum alkaline phosphatase and urinary hydroxyproline levels. which condition will the nurse most likely observe in the client's electronic medical chart?

Answer 1

The client's electronic medical chart will most likely state the condition called Paget's disease of bone. It is a disease involving problems with the remodelling of some bones. Patients with this disease have elevated serum alkaline phosphatase (ALP) and urinary hydroxyproline levels. ALP is a byproduct of osteoblast activity (osteoblasts are the cells that secrete new bone), while hydroxyproline plays a role in collagen stability. These two markers could indicate the increased osteoblastic activity that is present in this disease.

Answer 2

The nurse will most likely observe Paget's disease on the client's medical chart. Paget's disease interferes with the body's bone tissue recycling process and results in increased blood flow around affected bones, flushing extra alkaline phosphatase and urinary hydroxyproline from the body.