Answer is: d.) in a closed system.
Conservation of mass: during chemical reaction no particles are created or destroyed, the atoms are rearranged from the reactants to the products.
Closed system is a physical system that does not allow transfer of mass and energy in or out of the system.
For example, chemical reaction: 2CH₃OH + 3O₂ → 2CO₂ + 4H₂O.
1) There are four hydrogen atoms, one carbon atom, four oxygen atoms in this chemical reaction.
2) There are eight hydrogen atoms, two carbon atoms, eight oxygen atoms in this chemical reaction.