One of the most harmful weaknesses of the United States of America as a worldwide superpower is the fact that it's the number one enemy of most terrorist organizations of the world.
This is explained by the prevalence of American criteria and interests when it comes to the decisions of international organizations that regulate the international community (UN, NATO, among others), which are obviously seen as negative by these groups.
This weakness has resulted in terrorist attacks within the country as well as in dependencies abroad (embassies, etc).