The correct answer is option D
The specific internal response to harmful bacteria includes Helper T-cells, T-cells, B-cells. This kind of immunity is also known as adaptive immunity.
When ever any harmful bacteria invades the body, the immune cells recognize the harmful bacteria as antigen and starts building antibody against it. The macrophages shows the T-cells and B-cells, the parts of the pathogen against which the antibody has to be made.
Hence, the antigen triggers the production of antibodies specific to antigen.