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Ralph has normal blood clotting but has two brothers and a sister with hemophilia what are the most probable genotypes of Ralph parents

2 Answers

5 votes

Final answer:

The most probable genotypes of Ralph's parents are X^H X^h (carrier of hemophilia) for the mother and X^N X^N (normal clotting factor genes) for the father.

Step-by-step explanation:

The most probable genotypes of Ralph's parents can be determined by understanding the inheritance pattern of hemophilia. Hemophilia A and B are both X-linked recessive disorders, meaning they are passed down on the X chromosome. Males have one X chromosome and one Y chromosome, while females have two X chromosomes.

Ralph has normal blood clotting, so he must have received a normal clotting factor gene from one of his parents. Since Ralph's two brothers and sister have hemophilia, we can conclude that their mother is a carrier of the hemophilia gene. This means that Ralph's mother has one normal clotting factor gene and one hemophilia gene on one of her X chromosomes.

Ralph's father, on the other hand, does not have hemophilia since none of his children have inherited the disease. Therefore, Ralph's father must have two normal clotting factor genes on his X chromosome.

Based on this information, the most probable genotypes of Ralph's parents are:

  • Ralph's mother: X^H X^h (carrier of hemophilia)
  • Ralph's father: X^N X^N (normal clotting factor genes)

User Roddy
by
7.9k points
6 votes
his parents probably have hemophilia and he got the recessive trait hh and his siblings have dominant HH or Hh
User Xetera
by
7.5k points
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