Answer:
Substrate inhibitor, activator or a neurotransmitter.
Step-by-step explanation:
The original ligand was most likely a substrate inhibitor, activator or a neurotransmitter. A ligand is a small molecule that is able to bind to proteins by weak attractive forces such as ionic bond and hydrogen bonds etc. It also transmit signals in the process from one part to another part. It also act as inhibitor and activator of reactions in the process.