The two pollutants that destroys the ozone layer are CFC (Chlorofluorocarbons) and Methyl bromide. When the sun rays hit these molecules, they releases chlorine and bromine into the atmosphere. The chlorine and bromine reacts with the ozone present in the stratosphere and thus results in the depletion.
The origination of these pollutants are refrigerators, Air conditioners and aerosol cans.