It greatly improved commerce between America and the Asian powers. Before the Canal was built, the closest maritime route was to go down all the South American coast, to then cross from the Atlantic to the Pacific Ocean, over the south of Argentina, which was very costly because besides the long journey, the sea current at that point (south of Argentina) goes from the Pacific to the Atlantic, and it's known to be a hard passage to sail, what makes it a very slow point for the freighters.
And even though the two biggest seaports in the USA are located on its west coast, it's not always best to export all goods produced in the country throgh them, due to logistic issues. Depending on the region they were produced, sometimes it would be even cheaper to export them from New York/New Jersey, even before the Panama Canal.
Because of these reasons, even with the extreme high taxes to cross it (proportional to the bulk being tranported), it's way more profitable for american companies to export its goods and passengers on cruises to Asia or even countries/cities in American continent with their coast bathed by the Pacific, through the Canal.