You have R=unknown, something for which to solve;
T(total)=5 1/4 hours
D(distance) =350 miles.
Keep your calculations in miles per hour.
Distance ÷ Time
350 ÷ 5 1/4 (need to make the whole number a fraction and need to make mixed number a fraction)
350/1 ÷ 21/4=
350/1 × 4/21= 1400/ 21= 66 2/3