Answer:
The simplified expression is 8⁶.
Explanation:

When there is a negative exponent, that term gets moved to the opposite side of the fraction and the exponent becomes positive. Example:
8⁻² =
--- 8 is the same as
, if there is nothing left on one side, it is just 1
For this problem:

We move each of the terms to the opposite side of the fraction.

Then, when dividing exponents, you subtract them.
8¹⁰⁻⁴ = 8⁶
The simplified expression is 8⁶.